Combat Casualty Care
The crucible of war yields hard lessons on combat and incredible advances in military medicine. HJF-supported programs and facilities are studying polytrauma, testing and evaluating resuscitation methods and hemorrhage control, and increasing the understanding of tissue regeneration.
Uniformed Services University of the Health Sciences
HJF supports the Uniformed Services University of the Health Sciences in its traumatic tissue injury and regeneration research. HJF also supports an explosive blast extremity amputation model to investigate tissue remodeling following traumatic events.
Additionally, the development of heterotopic ossification is evaluated and biomarkers from the model are compared to biomarkers from samples taken from wounded warriors treated at Walter Reed National Military Medical Center.
To further investigate the mechanisms, HJF supports stem cell research and scaffold development by providing translational strategies.
Naval Medical Research Unit-San Antonio
HJF provides scientific, technical, administrative, management and programmatic services to Naval Medical Research Unit – San Antonio. Its mission is to conduct medical, craniofacial and directed energy biomedical research.
The unit’s Veterinarian Science Department and Combat Casualty Care and Operational Medicine Directorate are served by HJF. The directorate includes three departments: Expeditionary and Trauma Medicine, Immunodiagnostic and Bioassay, and Directed Energy Bioeffects and Human Systems Integration.
HJF’s efforts ensure successful research in five important areas:
- combat casualties
- hemorrhagic shock drugs
- therapeutic and diagnostic devices
- wound-healing biomarker discovery
- detection of microbial agents.
Naval Medical Research Center
HJF supports the Naval Medical Research Center Operational Undersea Medicine Directorate in its combat casualty care research efforts.
Regenerative Medicine Department
The center’s Regenerative Medicine Department maintains active research efforts in composite tissue transplantation, stem cell biology and translational medicine. Personnel also investigate wound healing on several topics, such as preventing heterotopic ossification and developing next-generation osseointegration prostheses techniques for the rehabilitation of amputees.
HJF also supports the translational medicine program in conducting both basic and clinical studies in wound healing and tissue regeneration. The team is furthering advanced diagnostics and treatment protocols by identifying the protein and gene expression patterns involved in wound healing.
The NeuroTrauma Department is developing novel strategies to prevent and treat combat casualties with particular attention given to developing early, far-forward interventions. This includes the Polytrauma Program, which studies traumatic brain injury (TBI) alone or in combination with hemorrhage or other injuries.
The Operational Medicine program is focused on emergent combat injuries with an emphasis on blast-induced traumatic brain injury. These research efforts include the study of blast biophysics, pathophysiological responses to blast, neurocognitive and behavioral consequences of blast exposure, and treatments for blast injury.
Naval Medical Center Portsmouth
HJF supports Naval Medical Center Portsmouth, the Navy’s oldest continuously operating hospital, and its Combat Trauma Research Group in conducting biomedical research in combat casualty care and mild traumatic brain injury.
The group is a collaboration of clinical researchers from Emergency Medicine and General Surgery with a shared interest in investigating the combat casualty care spectrum to improve outcomes from point of injury to definitive care. HJF assists the center with its model of severe hemorrhage, which is used to successfully study various damage control resuscitation techniques and support agents.
David Grant Air Force Medical Center
HJF supports David Grant Air Force Medical Center in its combat casualty care initiatives, specifically supporting investigations into hemorrhage control.
Resuscitative endovascular balloon occlusion of the aorta (REBOA) offers the greatest potential to change current resuscitative practices. A randomized trial that compares complete REBOA to endovascular variable aortic control (EVAC, also known as controlled titrated occlusion) is under way.
Additionally, HJF supports the development of optimal resuscitation practices and guidelines to minimize the progression of traumatic brain injuries and pulmonary contusions, as well as the development of cardiac dysfunction.