Infectious Disease Clinical Research Program

Infectious Disease Clinical Research Program

A Featured HJF Research Program

The Infectious Disease Clinical Research Program (IDCRP) is a research collaboration at Department of Defense military treatment facilities. Established in 2005 and centered at the Uniformed Services University of the Health Sciences (USU), the program has unique collaborative infectious disease research capability.

The Foundation supports IDCRP by providing administrative and management services to advance the program’s goal of reducing the impact of infectious diseases on the military population. The program is one of the Foundation’s largest.


The mission of IDCRP is to conduct infectious disease clinical research of importance to the military through a unique, adaptive and collaborative network; inform health policy and practice; and disseminate findings in peer-reviewed literature.

The program is focused on clinically important infectious disease threats to the service member and military community. The program has seven research focus areas: trauma/combat-related infections, deployment-related (travel), biodefense/emerging infectious diseases, respiratory disease, sexually transmitted infections, and HIV/AIDS.


The program was formed through an interagency agreement between the National Institute of Allergy and Infectious Diseases and USU. The institute recognized the untapped resource of the Department of Defense population and thus provided critical support to expand the portfolio of the existing Defense Department HIV clinical research network to encompass other infectious diseases of military importance.

Research Efforts

The program conducts HIV clinical research with the long-standing U.S. Military HIV Natural History Study. More than 5,000 beneficiaries have been enrolled in the prospective multi-center observational study cohort since 1986. Enrollment has been ongoing and continuous at seven military treatment facilities throughout the U.S. From this wealth of data, publications of research findings are ongoing.

Another benchmark protocol for the program is the Trauma Infectious Disease Outcomes Study, which follows wounded and injured soldiers from the fronts in Iraq and Afghanistan. The project is the first prospective evaluation of infectious disease complications, risk factors and long-term outcomes among patients with combat-related injuries.

The project is a collaborative effort among several medical treatment facilities: Landstuhl Regional Medical Center, Walter Reed National Military Medical Center, San Antonio Military Medical Center, Department of Defense research commands, U.S. Army Institute of Surgical Research, Walter Reed Army Institute of Research, USU and the Veterans Administration (St. Louis Veterans Administration Medical Center).

The study is highly visible and extremely relevant to the military. The U.S. Navy Bureau of Medicine and Surgery, through the Wounded Warrior Initiative, has provided funding to support this effort. Data from this project has provided input for clinical management guidelines.

The research program also has ongoing efforts looking at travel-related infections, sexually transmitted infections of importance to the military and respiratory infections.