New Open Funding Opportunities:

• Bone Marrow Failure Research Program

• Combat Readiness Medical Research Program

• Duchenne Muscular Dystrophy Research Program

• Joint Warfighter Medical Research Program

• Kidney Cancer Research Program

• Neurofibromatosis Research Program

• Orthopaedic Research Program 

• Parkinson's Research Program

• Rare Cancers Research Program

• Reconstructive Transplant Research Program

Upcoming Lunch and Learn Webinars

July 8: Duchenne Muscular Dystrophy, Joint Warfighter Medical, Kidney Cancer, Neurofibromatosis, Parkinsons, Prostate Cancer, Rare Cancers, Toxic Exposures

CDMRP Announcement: 

The ALSRP PCTA was modified on June 17, 2026 to reflect the following:

The regulatory application submission deadline was updated in Section 3.2.3. to further clarify that IND, IDE, or equivalent applications, if required, must be submitted to the relevant regulatory agency by the Pilot Clinical Trial Award application submission deadline.

Request for Information: Advanced Clinical Development and Licensure of an Adjuvanted Egg-based Influenza Vaccine – Due July 10 - 1 pm ET

Request for Information: Repurposing Equipment for Drug Delivery – July 23 - 1 pm ET

Request for Information: High Performance Antigen Diagnostics – Due July 17 – 1 pm ET

Request for Information: Protection Before Day One Vaccine: Advancing Broadly Protective Seasonal Influenza Vaccines with Pandemic Coverage – Due July 29 – 1 pm ET

New Vaccine Platforms (NVP) Program – Coming Soon 

Restorative & Health-Enhancing Sleep Time (REST)

Approximately 150 million Americans struggle with poor sleep, with insomnia alone affecting roughly 86 million adults—yet existing treatments fail more than 70% of them. Poor sleep more than doubles the risk for dementia, depression, hypertension, and diabetes, and contributes to an estimated $400 billion in economic burden annually.

REST will treat sleep as a controllable biological system—one that can be measured and improved at home. The program seeks proposals to develop validated, in-home systems that capture sleep-relevant physiology and diagnose insomnia and other forms of poor sleep—as well as noninvasive, closed-loop systems that adapt interventions to the user’s real-time physiology throughout the night.

Notice ID: ARPA-H-SOL-26-159

Brain Repair of Any Injured Neural Structure (BRAINS) Exploratory Topic 

Millions of people live with permanent disabilities caused by brain injury, disease, or aging, yet current treatments cannot repair damaged brain tissue or restore lost function. Instead, patients rely on therapies that help them adapt, meaning many remain dependent on long-term care and never regain full independence.

The BRAINS solution is to pioneer regenerative approaches that can rebuild the brain, specifically by developing graftable precursor tissues for different brain regions and demonstrating that these can be implanted and integrated to restore function. The initiative focuses on engineering region‑specific brain tissue and proving it can be successfully connected in the brain, with the goal of reversing damage and restoring abilities lost to injury or disease.

Using natural brain development as a guide, BRAINS is focused on two technical areas, both essential for later steps in repairing damaged brain tissue with working tissue:

• Technical area 1: teams will design developmental mimicking or tissue engineering methods capable of generating precursor tissue for a part of the brain other than neocortex.  
• Technical area 2: teams will provide proof-of-concept for surgical engraftment into adult brains of non-human fetal precursor tissues for their selected brain area

Key Dates

• Solution Summary due: July 9, 2026 at 5:00PM ET
  A solution summary is required to submit a full proposal.
• Full Proposal due: August 6, 2026 at 5:00PM ET
  After submission of a solution summary, proposers will either be encouraged or discouraged from submission of a full proposal. It is strongly recommended that only proposers who are encouraged to submit a full proposal do so.

ICYMI – MTEC released its pre-announcement for the Military Medical Prototype Advancement (MPAI) with 14 focus areas: 

• Focus Area 1: Policies and practices for cross-cutting prevention
• Focus Area 2: Fostering Service member physical fitness through integrated primary prevention
• Focus Area 3: Identify and reduce barriers to help-seeking
• Focus Area 4: Prophylactic Solutions to Prevent Battlefield and Complex Traumatic Wound Infections in Austere or Contested Environments
• Focus Area 5: Pathogen Agnostic Countermeasures for the Treatment of Sepsis Caused by Wound Infection
• Focus Area 6: Knowledge Product Solutions for the Prevention of Infection in Traumatic Penetrating Wounds
• Focus Area 7: Bacterial Diarrhea Prevention
• Focus Area 8: Dengue Fever Prevention and/or Treatment Solutions
• Focus Area 9: Prevention and Treatment of Emerging Infectious Diseases
• Focus Area 10: Musculoskeletal Injury Treatment
• Focus Area 11: Operational Suitability of Existing Pain Treatments
• Focus Area 12: Repurposing and Novel Delivery of Approved Compounds
• Focus Area 13: Development of Novel Non-Addictive Analgesics
• Focus Area 14: Advanced Anesthesia and Procedural Pain Solutions

Autonomous Closed Loop Control Mechanical Ventilation (ACLCMV) – Due July 15

This RPP seeks to develop an autonomous closed-loop mechanical ventilation system capable of automatically adjusting ventilation settings based on patient physiological responses for aeromedical evacuation, prolonged field care, and other resource-limited environments.

• Awards: One award anticipated
• Period of Performance: Up to 12 months
• Proposers Conference: Wednesday, July 2, 2026 at 11:00 AM ET - Register 
• Enhanced White Paper Due: July 15, 2026 at noon ET

PRimer and prObe Manufacturing PlaTform (PROMPT) – Due July 24

This solicitation, issued by the MTEC Consortium, represents a Request for Project Proposals (RPP) for MTEC in support of the Defense Threat Reduction Agency (DTRA). Military relevance is a critical component of the Solution Brief submission. Strategic oversight for the award(s) supported by this RPP will be provided by the Joint Science and Technology Office.

This RPP is focused on the development of a fully automated, man-portable, and ruggedized prototype platform for the on-demand, expeditionary manufacturing of clinical-quality nucleic acid primers and probes. This system must be designed for operation in far forward or austere environments by non-specialist personnel.

• Awards: One or more awards anticipated
• Period of Performance: Up to 24 months
• Proposers Conference: Thursday, July 8, 2026 at 2:00 PM ET - Register
• Teaming Connect: Tuesday, July 14, 2026 at 2:00 PM ET - Register
• Enhanced White Paper Due: July 24, 2026 at noon ET

Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI)

The PRIMED-AI program seeks to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. 

PRIMED-AI will be a uniquely synergistic, catalytic, cross cutting way of transforming the delivery of precision medicine through the emerging medical AI landscape.

The NIH Common Fund is now accepting applications for PRIMED-AI in the following areas:

• The Validation Center opportunityRFA-RM-27-014invites applications for a center which will serve as an independent hub for third party verification, validation, and uncertainty quantification of AI-enabled tools developed by the program.
  • Applications are due: October 2, 2026, by 5:00 PM local time of applicant organization

• The Logistics Center opportunity (invites applications for a center which will provide the administrative infrastructure necessary to facilitate and coordinate PRIMED-AI awardee activities to maximize the impact of the program.  The Logistics Center will provide administrative infrastructure through three integrated cores: Administration, Evaluation, and Outreach.
  • Applications are due: October 2, 2026, by 5:00 PM local time of applicant organization

• The Development and Testing of a Multi-use Frameworks Playbook opportunity RFA-RM-27-011invites applications for projects to develop and test standardized processes that will help organize and support the emerging multimodal-AI field. Such frameworks will support responsible use of PRIMED-AI models, error mitigation and technical management of data and algorithms, data ontology/linkage, and preparation for regulatory approval.
  • Applications are due: October 9, 2026, by 5:00 PM local time of applicant organization

• The Data-to-Model: An Academic-Industrial Partnership (D2M-AIP) opportunityRFA-RM-27-012invites applications for projects that will integrate and harmonize novel multiscale, multimodal data with clinical imaging data as well as develop and test truly novel AI-enabled, image-centered, multimodal clinical decision support tools. The purpose of this opportunity is to support multi-sector and multi-disciplinary research teams, including investigators from both academia and industry, to create mutually beneficial opportunities for partners in the pre-competitive development stage.
  • Applications are due: October 19, 2026, by 5:00 PM local time of applicant organization

• The Model-to-Clinic (M2C) opportunityRFA-RM-27-013 invites applications for projects that take clinical decision support tools from validated prototypes to clinical applications. M2C projects are expected to have high potential for demonstrable, positive impact on patient outcomes and/or healthcare processes.
  • Applications are due: October 19, 2026, by 5:00 PM local time of applicant organization

Pre-recorded informational webinars will be posted to the PRIMED-AI website at a later date.

Sign up for the PRIMED-AI listservto stay up to date on future announcements.