Andrés F. Londoño

Dr. Londono is a veterinarian and infectious disease scientist specializing in the biology and ecology of emerging and re-emerging zoonotic infections. With extensive expertise in translational and preclinical animal models, his research focuses on the complex dynamics between tick-borne pathogens, their vectors, and their animal and human hosts. Currently, Dr. Londono serves as an Assistant Professor and scientist in the laboratory of Dr. J. Stephen Dumler at USUHS. His research investigates the molecular interactions between rickettsial agents and their hosts, specifically targeting vascular permeability—a major pathogenetic feature of rickettsial diseases. Dr. Londono recently made the remarkable discovery that specific calcium channel antagonists and chelators prevent vascular permeability in vitro. Subsequent in vivo studies revealed the critical role that calcium ion flux plays in regulating the innate immune responses required for host resistance to Rickettsia spp.

Dr. Londono’s overarching goal is to advance the diagnosis, treatment, and prevention of tick-borne pathogens. A prime example of this translational focus is his recent publication detailing a novel strategy for developing radiation-inactivated vaccines for Lyme disease. By demonstrating that a synthetic antioxidant complex (MDP) protects Borrelia burgdorferi epitopes during sterilizing gamma-irradiation, he has identified a highly promising approach for creating effective whole-cell vaccines.