Calin Nicolescu, PhD
BS, Biomedical Engineering, Boston University
PhD, Biomedical Engineering, Case Western Reserve University
My research aims to understand the structural and biophysical mechanisms of liposomes as well as improving nucleic acid delivery with disease-targeted lipid nanoparticles (LNPs). I am interested in studying the roles of different lipids incorporated into formulations and using that knowledge to create new preventative or therapeutic products for infectious diseases and cancer. I bring a quantitative perspective to formulation design and characterization with my engineering background while also focusing on their biological targets and interactions.
| Nicolescu C, Komla E, Rao M, Matyas GR, Alving CR. Mechanisms of Self-Assembly of Giant Unilamellar Vesicles in the Army Liposome Formulation (ALF) Family of Vaccine Adjuvants. Pharmaceutics. 2025;17(9):1092. Published 2025 Aug 22. doi:10.3390/pharmaceutics17091092 |
| Nicolescu C, Kim J, Sun D, Lu ZR. Assessment of the Efficacy of the Combination of RNAi of lncRNA DANCR with Chemotherapy to Treat Triple Negative Breast Cancer Using Magnetic Resonance Molecular Imaging. Bioconjug Chem. 2024;35(3):381-388. doi:10.1021/acs.bioconjchem.4c00001 |
| Nicolescu C, Schilb A, Kim J, et al. Evaluating Dual-Targeted ECO/siRNA Nanoparticles against an Oncogenic lncRNA for Triple Negative Breast Cancer Therapy with Magnetic Resonance Molecular Imaging. Chem Biomed Imaging. 2023;1(5):461-470. Published 2023 Mar 21. doi:10.1021/cbmi.3c00011 |
Institution Affiliations
HJF Associate Scientist in support of Laboratory of Adjuvant and Antigen Research (LAAR) the U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research (WRAIR)