Chen Lai, PhD
PhD, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai
Focus on biospecimen-based biomarker discovery and validation to facilitate diagnosis and prognosis for traumatic brain injury and related brain health. Commit to streamline ultra-sensitive detection of multi-level molecular biomarkers and support multi-omics profiling studies to develop novel POC biomarker assessment tools. Thrive to offer wet lab hands-on training to collaborators.
| Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia. Hannah D. Mason, Yvonne L. Latour, Christopher T. Boughter, Kory R. Johnson, Dragan Maric, Cayce E. Dorrier, Vivian A. Guedes, Chen Lai, Patrick C. Duncker, Alexis M. Johnson, Monica Manglani, Jessica M. Gill, Daniel P. Perl, Martin Meier-Schellersheim & Dorian B. McGavern. Nature Immunology 26, 1152–1167 (2025) |
| Devoto C, Vorn R, Mithani S, Meier TB, Lai C, Broglio SP, McAllister T, Giza CC, Huber D, Harezlak J, Cameron KL, McGinty G, Jackson J, Guskiewicz K, Mihalik JP, Brooks A, Duma S, Rowson S, Nelson LD, Pasquina P, Turtzo C, Latour L, McCrea MA and Gill JM (2023) Plasma phosphorylated tau181 as a biomarker of mild traumatic brain injury: findings from THINC and NCAA-DoD CARE Consortium prospective cohorts. Front. Neurol. 14:1202967. doi: 10.3389/fneur.2023.1202967 |
| Yu F, Iacono D, Perl DP, Lai C, Gill J, Le TQ, Lee P, Sukumar G, Armstrong RC. Neuronal tau pathology worsens late-phase white matter degeneration after traumatic brain injury in transgenic mice. Acta Neuropathol. 2023 Oct;146(4):585-610. doi: 10.1007/s00401-023-02622-9. Epub 2023 Aug 14. PMID: 37578550; PMCID: PMC10499978. |
| Vorn R, Devoto C, Meier TB, Lai C, Yun S, Broglio SP, Mithani S, McAllister TW, Giza CC, Kim HS, Huber D, Harezlak J, Cameron KL, McGinty G, Jackson J, Guskiewicz KM, Mihalik JP, Brooks A, Duma S, Rowson S, Nelson LD, Pasquina P, McCrea MA, Gill JM; CARE Consortium Investigators. Are EPB41 and alpha-synuclein diagnostic biomarkers of sport-related concussion? Findings from the NCAA and Department of Defense CARE Consortium. J Sport Health Sci. 2023 May;12(3):379-387. doi: 10.1016/j.jshs.2022.11.007. Epub 2022 Nov 18. PMID: 36403906; PMCID: PMC10199139. |
| Vorn R, Mithani S, Devoto C, Meier TB, Lai C, Yun S, Broglio SP, McAllister TW, Giza CC, Kim HS, Huber D, Harezlak J, Cameron KL, McGinty G, Jackson J, Guskiewicz KM, Mihalik JP, Brooks A, Duma S, Rowson S, Nelson LD, Pasquina P, McCrea MA, Gill JM. Proteomic Profiling of Plasma Biomarkers Associated With Return to Sport Following Concussion: Findings From the NCAA and Department of Defense CARE Consortium. Front Neurol. 2022 Jul 19;13:901238. doi: 10.3389/fneur.2022.901238. PMID: 35928129; PMCID: PMC9343581. |
| Guedes VA, Lai C, Devoto C, Edwards KA, Mithani S, Sass D, Vorn R, Qu B-X, Rusch HL, Martin CA, Walker WC, Wilde EA, Diaz-Arrastia R, Gill JM and Kenney K (2021) Extracellular Vesicle Proteins and MicroRNAs Are Linked to Chronic Post-Traumatic Stress Disorder Symptoms in Service Members and Veterans With Mild Traumatic Brain Injury. Front. Pharmacol. 12:745348. doi: 10.3389/fphar.2021.745348 |
Area of Research
Institution Affiliations
HJF Division Director of Bioanalysis for USU, NEU-MTBI2